Selective amyloid-β lowering agents
نویسندگان
چکیده
منابع مشابه
Selective Amyloid-\(\beta\) Lowering Agents
The amyloid-β peptide (Aβ), implicated in the pathogenesis of Alzheimer's disease (AD), is produced through sequential proteolysis of the Aβ precursor protein (APP) by βand γ-secretases. Thus, blocking either of these two proteases, directly or indirectly, is potentially worthwhile toward developing AD therapeutics. β-Secretase is a membrane-tethered pepsin-like aspartyl protease suitable for s...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2008
ISSN: 1471-2202
DOI: 10.1186/1471-2202-9-s2-s4